The type of research you are doing, the discipline/s your research falls into and the type/s of literature you are looking for will determine the database/s that will be most worthwhile to search.
BIOSIS Previews (select Biosys previews under 'search in'), has a broad focus on life sciences, covering Ecology and the Environment, Biomedicine and Agriculture. CAB Abstracts has a narrower focus, on Applied life sciences.
Large multi-disciplinary databases such as Google Scholar, Web of Science and Scopus cover scientific disciplines, as well as disciplines such as Education, Business, Arts and Humanities.
Key databases for searching the biomedical literature include PubMed and Ovid Medline.
To carry out a thorough search, searching at least two relevant databases is recommended. While there will be some overlap in content, you are likely to find unique literature that is not included in both databases.
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* Orduna-Malea, E., Ayllón, J. M., Martín-Martín, A., & Delgado López-Cózar, E. (2015). Methods for estimating the size of Google Scholar. Scientometrics. doi:10.1007/s11192-015-1614-6